What is the skin absorption rate for every 5-degree rise in temperature?

The skin absorption rate increases significantly with rising temperature, and a common understanding in toxicology and emergency response suggests that for every 5-degree increase in temperature, the skin absorption rate can increase by approximately 400%. This heightened absorption can occur because higher temperatures facilitate the permeability of the skin, making it easier for substances to penetrate and enter the bloodstream.

When the temperature rises, the skin's barrier function may be compromised, and the physiological changes associated (such as increased blood flow and metabolic activity) can further enhance the absorption of harmful substances. This concept is critically important for first responders in hazardous environments, as it emphasizes the need for protective measures in varying conditions to prevent exposure to toxic agents. Understanding this rate is essential for ensuring the safety of personnel and managing potential overdoses in emergency situations.